FIGURE 1.

Three approaches used to produce dideoxymycobactin analogs that vary in structure. Dideoxymycobactins are composed of mycobactic acid and cobactin such that they contain four chiral centers in the peptidic backbone, designated *1, *2, *3, and *4. The chiral centers *2 and *4 were associated with the two lysine groups and assumed to have the same stereochemistry as naturally occurring l-lysine. The chiral centers labeled *1 and *3 were previously unknown and required elucidation. DDMs were isolated or produced with varying acyl chains or substitutions at R₁ or R₂ as indicated.