Figure 11.

Quantitative analyses of the effects of DCX depletion on the abundance of focal actin accumulations in axons of hippocampal neurons. The data from the individual experiments described in Table 3 were pooled together to generate this graph, which shows the total number of focal accumulations of actin per axon of control or DCX-depleted cells, and the number of focal actin accumulations with or without lamellipodia per axon of control or DCX-depleted cells. DCX depletion reduces the frequency of focal actin accumulations with lamellapodia by ∼90%, whereas focal actin accumulations without obvious lamellipodia are reduced by ∼30%.