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. Author manuscript; available in PMC: 2009 Oct 5.
Published in final edited form as: Kidney Int. 1999 Jun;55(6):2390–2396. doi: 10.1046/j.1523-1755.1999.00466.x

Table 1.

Summary of left kidney and single nephron hemodynamic responses in the normal anesthetized rat

BP
mm Hg 		GRF RPF FF RVR
mm Hg/(ml/min) 		SNGFR QA PGC PT RA RE Kf
nl/sec/mm Hg
ml/min nl/min mm Hg 1010dyn × sec × cm−5
Group I (NM A; N = 6)
 Control 99±1 1.35±0.04 3.5±0.1 0.39±0.02 15±1 57±1 231±18 57±1 13±1 0.85±0.08 0.95±0.08 0.042±0.003
 +NMA 131±2 1.16±0.06 2.3±0.1 0.50±0.02 29±2 44±2 120±14 79±3 14±2 1.96±0.30 2.87±0.26 0.019±0.001
 P value <0.001 <0.01 <0.005 <0.005 <0.001 <0.005 <0.001 <0.001 NS <0.005 <0.001 <0.001
Group II (BOS + NMA; N = 7)
 Control 101±1 1.82±0.06 5.1±0.4 0.37±0.03 11±1 67±6 220±21 62±1 14±1 0.82±0.08 1.17±0.10 0.044±0.003
 +BOS + NMA 123±3a 1.72±0.08 3.5±0.2 0.49±0.02 19±1a 70±10a 197±30a 70±2a 14±1 1.31±0.17a 1.67±0.21a 0.037±0.005a
 P value <0.001 NS <0.05 <0.05 <0.001 NS NS <0.005 NS <0.01 <0.01 <0.05
Group III (LOS + NMA; N = 8)
 Control 100±1 1.52±0.08 4.5±0.5 0.36±0.02 13±1 54±3 176±15 59±2 14±1 1.06±0.10 1.36±0.13 0.043±0.003
 +LOS +NMA 125±3a 1.59±0.16 3.3±0.4 0.50±0.02 22±3 56±4a 153±26a 73±2a 14±1 1.58±0.20a 2.23±0.30a 0.033±0.003a
 P value <0.001 NS <0.05 <0.001 <0.005 NS NS <0.001 NS <0.05 <0.05 <0.05
Group IV (LOS + BOS + NMA; N = 5)
 Control 108±3 1.17±0.07 4.1±0.4 0.30±0.02 15±2 39±2 119±11 65±2 12±1 1.66±0.26 2.27±0.32 0.026±0.002
LOS+BOS + NMA 111±6 1.09±0.10 4.1±0.4 0.27±0.02 15±2 40±2 113±11 60±3 11±1 2.11±0.31 2.37±0.32 0.030±0.002
P value NS NS NS NS NS NS <0.05 NS NS <0.05 NS NS

Values are mean ± se. Group I (NMA), acute systemic nitric oxide inhibition with N-monomethyl l-arginine (NMA) alone; Group II (BOS+NMA), combination of both ET blockade with a non-peptide ETA and ETB receptor antagonist bosentan (BOS) and NMA; Group III (LOS + NMA), combination of both angiotensin II inhibition with a selective AT1 receptor blocker losartan (LOS) and NMA; Group IV (LOS+BOS+NMA) combined angiotensin II AT1 and endothelin ETA and ETB receptor antagonism during acute systemic NOS inhibition with NMA. Abbreviations are: BP, mean blood pressure; GFR, glomerular filtration rate; RPF, renal plasma flow; FF, filtration fraction; RVR, renal vascular resistance; SNGFR, single nephron GFR; QA, glomerular plasma flow. PGC, glomerular blood pressure; PT, proximal tubule pressure; RA, preglomerular arteriolar resistance; RE, efferent arteriolar resistance; Kf, glomerular capillary ultrafiltration coefficient; NS, not significant. P values show significant difference by paired t-test.

a

Significant difference between the change from control to experimental for BOS + NMA (Group II) or LOS + NMA (Group III) versus NMA alone (Group I)