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. Author manuscript; available in PMC: 2009 Oct 5.
Published in final edited form as: Immunity. 2007 Nov;27(5):763–774. doi: 10.1016/j.immuni.2007.10.008

Figure 2. Important role of Fyn and PKCθ in T-CD4 T cell selection.

Figure 2

(A) CD4 and CD8 cell profile in thymocytes, LN and splenic cells from Tg+Fyn-/-→Aβ-/- (left group) and WT+Fyn-/-→B6 (right group). The numbers in the dot plots show the percentages of gated CD4 and CD8 SP thymocytes.

(B) Percentage of CD4 SP thymocytes LN and splenic CD4 T cells in Tg+Fyn-/-→Aβ-/- (left group) and WT+Fyn-/-→B6 chimeras (right proup). Data are shown as mean ± SD from 3 and 4 mice, respectively.

(C) Percentage of NK1.1+TCRβ+ NKT cells in Tg+Fyn-/-→Aβ-/- (left group) and WT+Fyn-/-→B6 chimeras (right proup). Numbers indicate the percentages of NKT cells among total thymocytes.

(D) CD4 and CD8 profiles of thymocytes, LN and splenic cells from Tg+PKCθ-/-→Aβ-/- (left group) and WT+PKCθ-/-→B6 (right group). The numbers in the dot plots show the percentages of gated CD4 and CD8 SP thymocytes.

(E) Percentage of CD4 SP thymocytes, CD4 T cells in LN and spleen from Tg+PKCθ-/-→Aβ-/- (left group) and WT+PKCθ-/-→WT (right group) chimeric mice. Data are shown as mean ± SD from 4 and 3 mice, respectively.

(F) A partial defect in PKCθ-/- NKT cell generation. The percentage of thymic NK1.1+TCRβ++ NKT cells in Tg+PKCθ-/-→Aβ-/- (left two panels) and WT+PKCθ-/-→B6 chimeras (right two panels).

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