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. Author manuscript; available in PMC: 2009 Oct 5.
Published in final edited form as: Immunity. 2007 Nov;27(5):763–774. doi: 10.1016/j.immuni.2007.10.008

Figure 6. cTEC- and thymocyte-mediated T cell selection pathways.

Figure 6

E-CD4 T cells are positively selected through heterotypic interactions between DP thymocytes and MHC class II-expressing cTEC (pathway 1). Thymocyte-mediated T cell selection pathway select T-CD4 T cells and NKT cells through homotypic interactions between TCR on developing DP thymocytes with MHC class II or CD1d on DP thymocytes, respectively (pathway 2). Our studies indicate that the SAP/Fyn/PKCθ signaling cascade is a common pathway required for the generation of both T-CD4 T cells and immature NKT cells, while T-bet and IL-15R are selectively involved in the maturation of NKT cells. Whether E-CD4 T cells and T-CD4 T cells share similar molecular requirements for their maturation is currently unknown.

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