Table 1.
General characteristics of the study subjects, by neuropathologic diagnosis, age, gender, apoE genotype and postmortem interval (PMI). Means and standard deviations (SD) are given. Thirty-four of the DLB cases and 27 of the PD cases also met neuropathologic diagnostic criteria for AD.
| Diagnosis (N) | Age (SD)1 | Disease Duration, yrs (SD)2 | Gender (%M)3 | ApoE-ɛ4 (%)4 | PMI, hrs Median, mean (SD)5 |
|---|---|---|---|---|---|
| Normal (87) | 84.8 (6.9) | N/A | 51.7 | 26.4 | 2.7, 3.3 (2.8) |
| ILBD (26) | 86.6 (5.5) | N/A | 61.5 | 30.0 | 2.9, 3.1 (1.6) |
| PD (66) | 79.1 (6.9) | 10.6 (8.7) | 69.7 | 30.3 | 2.7, 3.8 (3.3) |
| DLB (40) | 80.7 (6.6) | 6.9 (4.7) | 65.0 | 55.0 | 3.1, 4.5 (4.7) |
| ADLB (85) | 83.4 (8.1) | 9.0 (4.7) | 50.6 | 55.3 | 3.0, 6.0 (8.9) |
| ADNLB (113) | 82.8 (9.5) | 7.3 (4.7) | 46.0 | 53.9 | 3.0, 6.3 (11.4) |
Group means were significantly different (p < 0.0001).
Group means were significantly different (p = 0.003).
Subjects with ADNLB differed in gender distribution from those with PD and DLB (P < 0.01 for the comparison with PD, p < 0.05 for the comparison with DLB); subjects with ADLB differed from those with PD (p < 0.05).
Normal subjects and ILBD subjects differed from those with DLB, ADLB and ADNLB in the proportion that were apoE-ɛ4 positive (p < 0.01 for comparisons with normal, p < 0.05 for comparisons with ILBD).
Group means were not significantly different. ILBD = incidental Lewy body disease; PD = Parkinson’s disease; DLB = dementia with Lewy bodies; ADLB = Alzheimer’s disease with Lewy bodies; ADNLB = Alzheimer’s disease with no Lewy bodies.