Table 3.
Neuropathological and neurochemical characteristics of the study subjects, by neuropathological diagnosis, CERAD neuritic plaque density, Braak neurofibrillary stage, substantia nigra (SN) pigmented neuron loss score and striatal tyrosine hydroxylase concentration (TH; ng/mg protein). Note that the lattermost was only available for a subset of the cases.
| Diagnosis (N) | Neuritic Plaque Density (SD)1 | Braak Neurofibrillary Stage (SD)1 | SN Pigmented Neuron Loss Score (SD)1 | Striatal TH (SD) N1 |
|---|---|---|---|---|
| Normal (87) | 1.26 (1.04) | 2.77 (0.95) | 0.39 (0.58) | 90.35 (92.75) 31 |
| ILBD (26) | 1.01 (0.93) | 2.85 (0.78) | 0.72 (1.02) | 45.86 (105.42) 13 |
| PD (66) | 1.29 (1.03) | 2.86 (0.97) | 2.71 (0.70) | 10.55 (14.41) 17 |
| DLB (40) | 2.20 (0.97) | 3.72 (0.85) | 2.15 (0.81) | - |
| ADLB (85) | 2.76 (0.47) | 5.22 (0.85) | 1.41 (0.96) | 99.7 (85.3) 14 |
| ADNLB (113) | 2.70 (0.48) | 4.71 (1.08) | 1.04 (0.94) | 75.53 (64.23) 13 |
1
Group means were significantly different (p < 0.0001). For striatal td concentrations, N for normal is 31, N for ILBD is 13, N for PD is 17, N for DLB is 2; N for ADLB is 14, N for ADNLB is 13. Abbreviations as given in Table 1.