Table 6.
Therapeutic plasma concentrations of antidepressants, and concentrations used in experimental rat studies
| Antidepressant | Clinical plasma concentrations | Plasma concentrations in rat infusion studies |
|---|---|---|
| mg/L | ||
| Fluoxetine1 | 150-500(Wille et al., 2008) | 314(Durand et al., 1999; Lee et al., 2007b) |
| Imipramine2 | 45-150(Wille et al., 2008) | 100 - 600(Daniel et al., 1981; Lee et al., 2007b) |
| Bupropion3 | 25-100(Wille et al., 2008) | 289 (max)(Lee et al., 2008 ; Suckow et al., 1986) |
1
N-Methyl-g-[4-(trifluoromethyl)phenoxy]benzenepropanamine.
2
(5-[3-(dimethylamino) propyl] -10,11-dihydro-5H-dibenz [b,f]-azepine monohydrochloride).
3
(±)-2-(tertbutylamino)-1-(3-chlorophenyl)propan-1-one