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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Brain Res Rev. 2009 Jun 23;61(2):185–209. doi: 10.1016/j.brainresrev.2009.06.003

Table 7.

Brain arachidonic acid cascade markers following chronic administration of each of three antidepressants to rats

Target Fluoxetine Imipramine Bupropion
Fatty acid kinetics
Arachidonic acid turnover in brain phospholipid ↑(Lee et al., 2007b) ↑(Lee et al., 2008 ) Nc(Lee et al., 2008 )
Enzymes
CPLA2 IVA ↑(Lee et al., 2007b; Rao et al., 2006) ↑(Lee et al., 2008 ) Nc(Lee et al., 2008 )
SPLA2 IIA Nc(Lee et al., 2007b; Rao et al., 2006) Nc(Lee et al., 2008 ) Nc(Lee et al., 2008 )
iPLA2 VIA Nc(Lee et al., 2007b; Rao et al., 2006) Nc(Lee et al., 2008 ) Nc(Lee et al., 2008 )
COX-1 Nc(Lee et al., 2007b) Nc(Lee et al., 2008 ) Nc(Lee et al., 2008 )
COX-2 Nc(Lee et al., 2007b) Nc(Lee et al., 2008 ) Nc(Lee et al., 2008 )
Eicosanoids
PGE2 Nc(Lee et al., 2007b) Nc(Lee et al., 2008 ) Nc(Lee et al., 2008 )
Transcription Factors
AP-2 Nc(Rao et al., 2006) ↑ (AP-2α but not AP-2β)(Lee et al., 2008 )
↓(Damberg et al., 2000)		 Nc(Lee et al., 2008 )
AP-1 Nc(Rao et al., 2006) Nc(Tamura et al., 2002) ?
GRE Nc(Rao et al., 2006) ? ?
PEA3 Nc(Frechilla et al., 1998; Rao et al., 2006) ? ?
NF-κB Nc(Rao et al., 2006) Nc(Lee et al., 2008 ) Nc(Rao et al., 2007a)
RNA stabilizing protein ↑(Rao et al., 2006) ? ?