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. Author manuscript; available in PMC: 2010 Oct 15.
Published in final edited form as: Biol Psychiatry. 2009 Jul 3;66(8):777–784. doi: 10.1016/j.biopsych.2009.05.019

Figure 3. The DOR1 agonist TAN-67 does not affect locomotion or sucrose preference and decreases blood alcohol concentration without inhibiting ethanol uptake.

Figure 3

(A) C57BL/6 mice (n=8) were injected s.c. with vehicle (saline or 5% DMSO), or 25 mg/kg of the DOR1 agonist TAN-67 or 6 mg/kg of the DOR2 antagonist NTB. Thirty minutes after injection locomotor activity (distance traveled) was measured for four hours. (B) C57BL/6 mice (n=9) trained to prefer sucrose were injected s.c. with vehicle (saline or 5% DMSO), 25 mg/kg TAN-67 or 6 mg/kg NTB. Thirty minutes after injection sucrose consumption was measured over a 4 hour period. (C) C57BL/6 mice were injected s.c. with vehicle (saline or 5% DSMO) 25 mg/kg TAN-67 or 6 mg/kg NTB. Thirty minutes after injection mice (n=9) were exposed to ethanol and water consumption for a 4 hour period in a 2-bottle choice paradigm and blood alcohol levels (BAC) were measured immediately afterwards. (***p<0.001).