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. Author manuscript; available in PMC: 2010 Oct 15.
Published in final edited form as: Biol Psychiatry. 2009 Jul 3;66(8):777–784. doi: 10.1016/j.biopsych.2009.05.019

Figure 4. The DOR1 antagonist BNTX blocks the effect of TAN-67, whereas the DOR2 antagonist NTB enhances the effect of TAN-67.

Figure 4

(A) C57BL/6 mice (n=9) were injected s.c. with vehicle (5% DMSO or saline), 25 mg/kg TAN-67, 10 mg/kg BNTX or 25 mg/kg TAN-67 + 10 mg/kg BNTX. (B) C57BL/6 mice (n=9) were injected s.c. with vehicle (5% DMSO or saline) 10 mg/kg NTB, 25 mg/kg TAN-67 or NTB + TAN-67. (C) C57BL/6 mice (n=9) were injected s.c. with vehicle (5% DMSO or saline) 5 mg/kg NTB, 12.5 mg/kg TAN-67 or NTB + TAN67. Thirty minutes after injection ethanol consumption was measured over a 4 hour period. (*p<0.05; **p<0.01).