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. Author manuscript; available in PMC: 2010 Oct 15.
Published in final edited form as: Biol Psychiatry. 2009 Jul 3;66(8):777–784. doi: 10.1016/j.biopsych.2009.05.019

Figure 8. Disruption of the MOR turns NTI into a DOR2-selective antagonist for drinking.

Figure 8

Naltrindole (NTI, 10 mg/kg) induced changes in ethanol consumption (A) and preference (B) in wild-type, DOR KO and MOR KO C57BL/6 mice (n=9). Thirty minutes after injection ethanol and water consumption was measured over a 4 hour period. Ethanol preference = ethanol consumption/(ethanol consumption + water consumption). (*p<0.05; **p<0.01).