Figure 8. Disruption of the MOR turns NTI into a DOR2-selective antagonist for drinking.
Naltrindole (NTI, 10 mg/kg) induced changes in ethanol consumption (A) and preference (B) in wild-type, DOR KO and MOR KO C57BL/6 mice (n=9). Thirty minutes after injection ethanol and water consumption was measured over a 4 hour period. Ethanol preference = ethanol consumption/(ethanol consumption + water consumption). (*p<0.05; **p<0.01).