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. Author manuscript; available in PMC: 2010 Sep 30.
Published in final edited form as: Adv Drug Deliv Rev. 2009 Jul 20;61(11):940–952. doi: 10.1016/j.addr.2009.07.002

Figure 1.

Figure 1

Intra tumoral vascular permeability permits entrapment of drug carriers. (A) Intact normal vasculature. (B) Semi porous tumor vasculature. Drug carriers selectively extravasate into tumor via pores [28]. This EPR targeting strategy provides a mechanism for extracellular drug carrier accumulation in the tumor, which may be further augmented via peptide-mediated targeting.