Table 1.

Hepatic microRNAs dysregulated in mice fed CDAA diet for 6, 18, 32 and 65 weeks. Analysis of variance with randomized block design identified 30 hepatic miRNAs that are altered P<0.01) upon feeding mice CDAA diet compared to CSAA diet. RNA from 4 mice on CSAA diet and 5 mice on CDAA diet at each time point was used for microarray analysis.

Gene Symbol	Fold Change				Parametric p-value	FDR False Discovery Rate
	6 week	18 week	32 week	65 week
miR-200c	1.00	0.84	1.00	2.67	0.000	0.004
miR-200b	1.00	1.00	1.00	2.53	0.001	0.010
miR-181d	0.77	0.45	4.21	2.40	0.000	0.005
miR-155	0.87	1.43	2.81	1.90	0.000	0.000
miR-487a	3.04	0.92	0.46	1.78	0.006	0.040
miR-181b	0.70	0.92	3.20	1.73	< 1e-07	< 1e-07
miR-223	0.47	1.84	2.82	1.62	< 1e-07	< 1e-07
miR-342-3p	0.51	1.54	1.73	1.40	0.000	0.000
miR-150	0.99	0.92	2.79	1.39	0.000	0.005
miR-99b	0.76	1.00	1.68	1.33	0.000	0.001
miR-214	0.80	0.98	1.73	1.32	0.002	0.017
miR-221	0.80	1.19	1.51	1.32	0.009	0.057
miR-195	0.90	1.02	1.67	1.29	0.000	0.000
miR-142-5p	0.54	1.03	2.19	1.28	0.005	0.035
miR-222	0.84	1.17	1.37	1.28	0.002	0.017
miR-34a	0.57	1.22	1.62	1.26	0.004	0.032
miR-16	0.88	1.12	1.72	1.16	0.000	0.000
miR-107	1.01	0.69	0.67	0.92	0.001	0.006
miR-30a	1.02	0.92	0.81	0.88	0.005	0.038
let-7a	1.10	0.66	0.62	0.85	0.005	0.038
miR-103	1.00	0.71	1.08	0.81	0.009	0.054
miR-30b	0.99	0.73	0.96	0.74	0.004	0.032
miR-30e	0.96	0.83	0.70	0.70	0.010	0.059
miR-323-5p	1.34	0.75	0.52	0.60	0.001	0.008
miR-27a	1.06	1.01	0.97	0.40	0.007	0.048
miR-802	1.00	0.74	0.71	0.28	0.000	0.000
miR-32	0.98	0.87	0.79	0.21	0.000	0.001
miR-17	0.83	0.99	1.45	0.90	0.000	0.003
miR-346	1.50	1.19	1.34	0.41	0.000	0.001
miR-20b	0.77	0.92	1.20	0.76	0.002	0.016