Table 2B. Liver pathology and miR expression in mice fed diet for 65 weeks.
| Diet | HISTOLOGY | miR-155-LNA-ISH | miR-155/18S rRNA (2−ΔCt) × 104 |
|---|---|---|---|
| CSAA | Steatosis – 75% | ||
| Inflammation – mild | 2+ | 4.14 | |
| Not NASH | 21% HEPATOCYTES + | ||
|
| |||
| CSAA | Steatosis – 90% | ||
| inflammation– mild | 2+ | 5.25 | |
| Not NASH | 24% HEPATOCYTES + | ||
|
| |||
| CSAA | Steatosis – 90% | ||
| Inflammation– mild | Not determined | 1.46 | |
| Not NASH | |||
|
| |||
| CSAA | Steatosis – 90% | ||
| Inflammation– mild | 1+ | 3.37 | |
| Not NASH | 6% HEPATOCYTES + | ||
|
| |||
| CDAA | Steatosis – 90% | ||
| Inflammation – moderate to severe | 3+ | 7.25 | |
| NASH | 52% HEPATOCYTES + | ||
|
| |||
| CDAA | Steatosis – 90% | ||
| Portal tract inflammation –moderate | 3+ | 6.83 | |
| NASH | 55% HEPATOCYTES + | ||
|
| |||
| CDAA | Steatosis – 75% | ||
| Inflammation – moderate | 1+ | 3.33 | |
| Not NASH | 19% HEPATOCYTES + | ||
|
| |||
| CDAA | Steatosis – 90% | ||
| Inflammation– moderate | 3+ | 8.38 | |
| NASH | 59% HEPATOCYTES + | ||