. Author manuscript; available in PMC: 2010 Oct 1.

Published in final edited form as: J Pain. 2009 Jul 22;10(10):1001–1011. doi: 10.1016/j.jpain.2009.06.002

Table 3.

A Partial list of Clinical Studies Using NMDA Receptor Antagonists

Clin. Model	Drug	Dose Regimen	Outcome	References
Hysterectomy	Ama	200 mg, iv, pre-op	Negative	48
Knee	Dex	200 mg, po, pre-op	Negative	124
Abdominal	Dex	120 mg, im, pre-op	Negative	58
Hysterectomy	Dex	27 mg, po, peri-op	Negative	76
CNP	Ket	> 100 mg/d, po	Positive	41
PHN	Dex	125 mg/d, po	Positive	64
PHN	Ket	0.15 mg/kg/hr × 7 d	Positive	40
NCP	Ket	400 mg/day, sc	Positive	82
NCP	Ama	200 mg/3 hr, iv	Positive	101

Legends: Knee: knee surgery; Abdominal: abdominal surgery; CNP: chronic neuropathic pain; PHN: postherpetic neuralgia; NCP: neuropathic cancer pain; Ama: amantadine; Dex: dextromethorphan; Ket: ketamine; Pre-op: pre-operative; Peri-op: peri-operative; PO: oral; iv: intravenous; sc: subcutaneous; im: intramuscular.