Figure 4. Enhanced alterations in expression of EMT-related genes during diet-induced NASH in Ptc+/- mice.
QRT-PCR analysis was done to assess changes in expression of several EMT-related genes in total liver RNA from the mice described in the legend to Figure 3 (a) tgfβ, (b) α sma, (c) mmp9, (d) timp1, (e) bmp7, (f) keratin-7. Results are expressed as fold change relative to the respective chow-fed control group and graphed as mean ± SEM. *P < 0.05 vs WT group