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. Author manuscript; available in PMC: 2010 Sep 30.
Published in final edited form as: Adv Drug Deliv Rev. 2009 Aug 11;61(11):977–985. doi: 10.1016/j.addr.2009.07.014

Fig. 3.

Fig. 3

Generation of antibodies in patients against epitope hot spots identified by the mouse monoclonal antibodies. Human serum samples of patients before (open bars) and after (closed bars) treatment with anti-mesothelin immunotoxin SS1P were analyzed in the competition assay used for mapping topographical epitopes (Fig. 2A). Averages and standard deviations of 4 different patient samples are shown. Adapted with permission from The Journal of Immunology Vol. 177, 8822–8834, 2006; copyright 2006 The American Association of Immunologists, Inc.