Table 4. Mean peak or trough scores ratings (SE) of Response Variables sensitive to one or more of the active drug conditions.
Placebo | Hydrocodone/Acetaminophen 30 mg/975 mg | Morphine 45 mg | |
---|---|---|---|
Mean (SD) Addiction Research Center Inventory Scores | |||
Phenobarbital-Chorpromazine-Alcohol* (sedation) |
7.6 (1.0) | 5.4 (0.9) | 5.2 (0.8) |
Morphine-Benzedrine ** (euphoria) |
3.3 (0.8) | 4.6 (0.9) | 3.5 (1.0) |
Lysergic Acid Diethylmide **↓ (dysphoria, agitation) |
4.7 (0.8) | 4.2 (0.6) | 3.6 (0.5) |
Mean (SD) Drug Liking Ratings, mm | |||
Craving*↓ | 23.0 (12.4) | 11.1 (4.2) | 7.5 (3.6) |
Strong desire*↓ | 21.2 (8.2) | 12.5 (5.0) | 16.5 (7.8) |
Mean (SD) Drug Effect Ratings, mm | |||
Sedated*¶ | 18.0 (8.0) | 3.7 (1.5) | 1.9 (1.0) |
Confused*¶ | 14.8 (6.8) | 5.6 (3.2) | 5.3 (2.2) |
Nauseated*¶ | 10.2 (6.2) | 0.6 (0.3) | 1.5 (1.3) |
Good Drug Effect** | 24.8 (10.0) | 10.2 (4.9) | 15.9 (8.0) |
Impaired* | 16.2 (7.3) | 5.3 (3.5) | 9.6 (5.4) |
Stoned* | 17.1 (9.2) | 12.4 (6.2) | 8.3 (6.6) |
P <0.05
P <0.001
Interaction Effect
Decline in trough score