Fig. 1.

Transplantation of ES-derived hepatic progenitor cells. Embryonic stem cells can be differentiated towards a hepatic progenitor cell-phenotype (ES-HPC). After transplantation of wild-type ES-HPCs into immunosuppressed FAH^-/- mice, engraftment of single cells (arrowheads) and formation of regeneration nodules after ES-HPC proliferation (arrows) can be observed. The 3-amino-9-ethylcarbazole-substrate staining of the cells demonstrates the presence of FAH-enzyme activity in the FAH^-/- recipient liver. Bar 25 μm