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Western blot analysis of cleaved caspase-12 prepared from extracts of control EC (Con) or EC exposed to simulated ischemia (SI) without or with APC treatment. Note that treatment with 3 μmol/l SB203580 (SB) or with 10 μmol/l LY294002 (LY) during APC abolished the inhibitory effect of APC on caspase-12 cleavage during SI. Data are representative of three independent experiments with similar results
