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Plasma concentrations of 5-fluorouracil (5-FU) in 56 patients with esophageal cancer. A total of 8 measurements were made per patient: 5 PM on days 3, 10, 38 and45, and 5 AM on days 4, 11, 39 and 46. Closed circle: the cisplatin (CDDP) group (N=49), open circle: the nedaplatin (NDP) group (N=7). The bars represent the SD. * P<0.05; significant differences were observed in the CDDP group, but not in the NDP group.
