Table 3.
Area Under the Concentration-Time Curve Values (AUC120h, mg*h/L) of 5-Fluorouracil (5-FU) in 56 Japanese Patients with Esophageal Squamous Cell Carcinoma
| CDDP | NDP | |
|---|---|---|
| N=49 | N=7 | |
| 1st cycle / 1st course | 11.1±4.8 | 11.0±4.6 |
| 2nd cycle / 1st course | 16.8±6.4 | 15.3±7.3 |
| 1st cycle / 2nd course | 10.7±5.2 | 10.6±4.4 |
| 2nd cycle / 2nd course | 16.0±5.4 | 15.9±6.8 |
CDDP: cisplatin, NDP: nedaplatin. Systemic exposure to 5-FU was assessed as the AUC120h, calculated as 120 hours x the average of 2 measurements. There was no significant difference between the 2 groups at each of the 4 cycles.