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. 2009 Oct 13;4(10):e7424. doi: 10.1371/journal.pone.0007424

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Im et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A-D in situ hybridization showing the expression of the eEF-2K transgene in wild-type (A) and hip-eEF-2K-tg mice (C) or a higher magnification in wild-type (B) and hip-eEF-2K-tg mice (D). Exclusive expression of the transgene mRNA was found in the CA1, CA3, and dentate gyrus, but not the CA2 region. E. Representative Western blots showing the expression of the total eEF-2K (including the endogenous and transgenic eEF-2K; upper panel), phospho-eEF-2 (phosph) (middle panel), and the total eEF-2 (including phospho- and dephospho-eEF-2; low panel) in the hippocampi from wild-type (wt) and hip-eEF-2K-tg (tg) mice. F. Quantitative analysis of the expression of eEF-2K in wt (n = 6) and tg mice (n = 5). ***, p<0.001, Student's t test. G. Quantitative analysis of the expression of phospho-eEF-2 in wt (n = 5) and tg mice (n = 5). **, p<0.01, Student's t test. H and I. Representative microphotography of Nissl staining and Golgi staining in wild-type (h) and hip-eEF-2K-tg mice (i).