Figure 6.

Potency of different vasodilators after chronic 2-nitrooxyethylammoniumnitrate (AEN) or triethanolamine trinitrate (TEAN) treatment. Relaxation was assessed by recording isometric tension in aortic segments from wild-type mice. The effect of AEN treatment in vivo (150 µg·h⁻¹ per 3 days) on relaxation to acetylcholine (ACh) (A), glyceryl trinitrate (GTN) (C) and AEN (E) was tested. Similarly, the effect of TEAN (140 µg·h⁻¹ per 3 days) on relaxation to ACh (B), glyceryl trinitrate (GTN) (D) or TEAN (F) was assessed. For both nitrates dimethyl sulphoxide (DMSO) was used as a solvent control. Data show mean ± SEM of 12–19 (AEN) and 7–12 (TEAN) independent experiments with tissue from at least five animals per group. *P < 0.05 versus DMSO solvent control.