Figure 7.

Potency of different vasodilators after chronic glyceryl trinitrate (GTN) treatment. Relaxation was assessed by recording isometric tension in aortic segments from wild-type mice. The effect of GTN treatment in vivo (50 µg·h⁻¹ per 3 days) on relaxation to acetylcholine (ACh) (A), GTN (B), 2-nitrooxyethylammoniumnitrate (AEN) (C) and triethanolamine trinitrate (TEAN) (D) was assessed. Data are mean ± SEM of 12–18 (ACh, GTN, TEAN) or 27–28 (AEN) independent experiments with tissue from at least seven animals per group. *P < 0.05 versus ethanol (EtOH) solvent control.