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. 2009 Jun 25;158(2):510–520. doi: 10.1111/j.1476-5381.2009.00303.x

Table 1.

Potencies and efficacies of organic nitrates in aorta from wild-type and ALDH-2−/− mice

AEN 2nd AEN (tachyphylaxis)
Group Potency (pD2)# Efficacy (%)# Potency (pD2) Efficacy (%)
Wild-type 6.08 ± 0.10 (n= 20) 81 ± 4 (n= 20) 5.87 ± 0.09 (n= 16) 77 ± 2 (n= 16)
ALDH-2−/− 5.85 ± 0.11 (n= 20) 75 ± 2 (n= 20) 5.68 ± 0.12 (n= 16) 71 ± 5 (n= 16)

TEAN 2nd TEAN (tachyphylaxis)

Group Potency (pD2) Efficacy (%) Potency (pD2) Efficacy (%)
Wild-type 4.82 ± 0.12$ (n= 20) 71 ± 4 (n= 20) 3.69 ± 0.12§ (n= 16) 58 ± 8 (n= 16)
ALDH-2−/− 4.22 ± 0.12& (n= 15)* 69 ± 3 (n= 15) 3.78 ± 0.11 (n= 16) 48 ± 4 § (n= 16)

NPME 2nd NPME (tachyphylaxis)

Group Potency (pD2) Efficacy (%) Potency (pD2) Efficacy (%)
Wild-type 4.69 ± 0.13$ (n= 30) 68 ± 3$ (n= 30) 4.47 ± 0.17$ (n= 16) 75 ± 2$ (n= 16)
ALDH-2−/− 4.47 ± 0.09& (n= 25) 63 ± 3& (n= 25) 4.27 ± 0.12& (n= 14) 56 ± 3& (n= 14)

ALDH-2−/−, aldehyde dehydrogenase knockout; AEN, aminoethyl nitrate; TEAN, triethanolamine trinitrate; NPME, methyl-3-nitrooxypropanoate.

*

P < 0.05 versus wild-type

§

P < 0.05 versus first concentration–relaxation response curve

$

P < 0.05 versus AEN wild-type

&

P < 0.05 versus AEN knockout.

#

Potency is –log EC50 and efficacy is defined as maximal relaxation obtained with the highest concentration of the vasodilator used.