Table 1.
AEN | 2nd AEN (tachyphylaxis) | |||
---|---|---|---|---|
Group | Potency (pD2)# | Efficacy (%)# | Potency (pD2) | Efficacy (%) |
Wild-type | 6.08 ± 0.10 (n= 20) | 81 ± 4 (n= 20) | 5.87 ± 0.09 (n= 16) | 77 ± 2 (n= 16) |
ALDH-2−/− | 5.85 ± 0.11 (n= 20) | 75 ± 2 (n= 20) | 5.68 ± 0.12 (n= 16) | 71 ± 5 (n= 16) |
TEAN | 2nd TEAN (tachyphylaxis) | |||
Group | Potency (pD2) | Efficacy (%) | Potency (pD2) | Efficacy (%) |
Wild-type | 4.82 ± 0.12$ (n= 20) | 71 ± 4 (n= 20) | 3.69 ± 0.12§ (n= 16) | 58 ± 8 (n= 16) |
ALDH-2−/− | 4.22 ± 0.12& (n= 15)* | 69 ± 3 (n= 15) | 3.78 ± 0.11 (n= 16) | 48 ± 4 § (n= 16) |
NPME | 2nd NPME (tachyphylaxis) | |||
Group | Potency (pD2) | Efficacy (%) | Potency (pD2) | Efficacy (%) |
Wild-type | 4.69 ± 0.13$ (n= 30) | 68 ± 3$ (n= 30) | 4.47 ± 0.17$ (n= 16) | 75 ± 2$ (n= 16) |
ALDH-2−/− | 4.47 ± 0.09& (n= 25) | 63 ± 3& (n= 25) | 4.27 ± 0.12& (n= 14) | 56 ± 3& (n= 14) |
ALDH-2−/−, aldehyde dehydrogenase knockout; AEN, aminoethyl nitrate; TEAN, triethanolamine trinitrate; NPME, methyl-3-nitrooxypropanoate.
P < 0.05 versus wild-type
P < 0.05 versus first concentration–relaxation response curve
P < 0.05 versus AEN wild-type
P < 0.05 versus AEN knockout.
Potency is –log EC50 and efficacy is defined as maximal relaxation obtained with the highest concentration of the vasodilator used.