Figure 3.
Effects of NCX 2057 and ferulic acid (FA) on mechanical allodynia in rats with chronic constriction injury (CCI). Effects of vehicle, NCX 2057 (175 µmol·kg−1), FA (175 µmol·kg−1) or gabapentin (175 µmol·kg−1) on nociceptive threshold [as paw withdrawal threshold (PWT)] in ipsilateral-CCI paws are shown in A and from contralateral non-lesioned paws in B. In C and D, these effects are expressed as area under curve (AUC) from the time courses shown in A and B. For NCX 2057, FA, gabapentin (GBP) and vehicle in CCI paws, data are shown in C. Corresponding data for the non-lesioned, contralateral paw are shown in D. Compounds were given by s.c. injection and mechanical threshold was measured with an analgesimeter (modified Randall–Selitto method) before treatment (pre-test) and from 15 to 60 min after treatment. In panel B, PWT responses over time obtained following individual treatments were integrated (AUC) and are presented as percent of response to vehicle. Data represents mean ± standard error of mean of 6–8 animals for each experimental group. **P < 0.01 versus respective vehicle treatment.