Figure 4.

Effects of NCX 2057 and ferulic acid (FA) on mechanical hyperalgesia and prostaglandin E₂ (PGE₂) formation in carrageenan-induced inflammation in mice. (A) Responses to mechanical stimulation with von Frey filaments and (B) contents of PGE₂ metabolites in paw exudates were determined in sham or carrageenan injected animals treated locally with vehicle NCX 2057 or FA at the indicated doses. Mechanical sensitivity and PGE₂ formation, estimated by determination of the two major metabolites, 13, 14-dihydro-15-keto PGE₂ and 13, 14-dihydro-15-keto PGA2 were determined 4 h after carrageenan injection. Data represent mean ± standard error of mean of 8–10 animals for each experimental group. *P < 0.05, **P < 0.01 versus vehicle treatment, #P < 0.05 versus sham treatment. In this set of experiments, naproxen, administered orally as a positive control, had an ID₅₀ of 2.3 mg·kg⁻¹.