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Scheme of possible mechanisms underlying the antagonism between cetuximab and oxaliplatin, involving modulation of redox status. CTX, cetuximab; EGF, epidermal growth factor; GSH, glutathione; PI3K, phosphatidylinositol-3 kinase; PIP2, phosphatidylinositol bisphosphate; PIP3, phosphatidylinositol trisphosphate; PTEN, phosphatase and TENsin homologue, ROS, reactive oxygen species; shRNA, short hairpin RNA.
