Figure 1. PARP-1 gene deletion promotes atherosclerotic plaque reduction in an animal model of atherosclerosis.

(A) Aortas from the different experimental groups were formalin (PBS)-perfused and atherosclerotic plaques were visualized by en face Oil-Red-O staining. (B) Quantitation of plaque size and number (in parentheses) were determined as described[15]; P value (<0.05) *compared to ApoE^−/− RD, †compared to ApoE^−/− HF (16 weeks), and ‡compared to DKO mice on RD.