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. Author manuscript; available in PMC: 2009 Oct 6.
Published in final edited form as: FEBS Lett. 2007 Oct 12;581(27):5199–5206. doi: 10.1016/j.febslet.2007.10.007

Fig. 4.

Fig. 4

Self-activation of Th1 cells through IFN-γ (A) IL-12Rβ2 mRNA levels in wild-type (black empty squares) and Ifngr1−/− (green empty circles) cells as a function of IL-27 concentrations. (B) IL-12Rβ2 mRNA levels in wild-type (black filled squares) and Ifngr1−/− (green filled circles) cells as a function of IL-27 concentrations when IL-12 is present at 10 ng/ml concentration. (C) Simulation of IL-12Rβ2 mRNA levels in Ifngr1−/− cells using fitted parameters (see Methods). Empty and filled green lines denote were obtained using zero and saturating IL-12 concentrations, respectively. (D) Proportion of IFN-γ positive wild-type cells as a function of IL-27 in wild-type (BALB background, (black empty squares) and Stat4−/− cells (BALB background, blue empty diamonds). (E) T-bet mRNA levels in Stat1−/− cells, 5 days after induction with IL-27 in the presence (red filled triangles) or absence (red empty triangles) of IL-12 (10 ng/ml). (F) T-bet mRNA levels in wild-type (black empty squares), and Ifngr1−/− cells in the absence (green empty cicles) or presence of 10 ng/ml IL-12 (green filled circle) after induction with different concentrations of IL-27.