Figure 1. SDF-1 is up regulated in the lungs and right ventricles of neonatal mice with pulmonary hypertension.
a. Neonatal mice with pulmonary hypertension following exposure to hypoxia for 1 or 2 wk (n = 5–7 mice/group) had a 2 fold increase in SDF-1 protein expression as compared to normoxia (n= 5–7 mice/group). * p<0.005 RA vs Hyp 1 wk; ** p<0.005 RA vs Hyp 2 wk.
b. Neonatal mice with pressure overload induced RVH following exposure to hypoxia for 1 or 2 wk ((n = 5–7 mice/group) had a 2 fold increase in SDF-1 protein expression as compared to normoxia. * p<0.0001, RA vs Hyp 1 wk; ** p<0.0001, RA vs Hyp 2 wk.