TABLE I.
Gm in EDL muscle fibers before AP firing
Experimental conditions | GmS | GmS,50 | GKS | GClS | GClS,50 |
µS/cm2 | µS/cm2 | µS/cm2 | µS/cm2 | µS/cm2 | |
50 µM BTS | 1,458 ± 70 (n = 26/7) | 361 ± 21 (n = 15/4) | 144 ± 16 (n = 13/6) | 1,314 ± 72 | 217 ± 26 |
50 µM BTS + 10 µM glibenclamide | 1,252 ± 42 (n = 24/4) | 524 ± 27 (n = 11/2) | 195 ± 32 (n = 6/2) | 1,057 ± 53 | 329 ± 42 |
50 µM BTS + 100 µM 5-HD | 1,609 ± 82 (n = 14/2) | ND | ND | NA | NA |
50 µM BTS + 100 µM 9-AC + 0.01 µM TTX | 143 ± 13 (n = 9/2) | ND | ND | NA | NA |
The subscript S indicates values for Gm before AP firing under the various experimental conditions as determined using the classical technique (Fig. 1 and Eq. 1). GmS,50 represents Gm before AP firing at 50 mM Cl−. GKS and GClS represent component conductances of GmS for K+ and Cl−, respectively, whereas GClS,50 represents the component conductance of GmS,50 for Cl−. All data have been presented as means ± SEM. n represents fibers/muscles. NA, not applicable.