TABLE II.
AP firing frequency | A1 | τ1 | τ1 (APs) | A2 | τ2 | τ2 (APs) | β | β(APs) |
µS/cm2 | s | µS/cm2 | s | s | ||||
6 Hz (n = 8) | −779 ± 78 | 66 ± 8a | 199 ± 24 | 3,400 ± 431b | 1,088 ± 79a | 3,264 ± 237b | 79 ± 14 | 238 ± 43 |
15 Hz (n = 18) | −809 ± 39 | 27 ± 1a | 189 ± 10 | 5,426 ± 494 | 352 ± 12a | 2,466 ± 81 | 34 ± 2 | 237 ± 12 |
30 Hz (n = 13) | −706 ± 50 | 18 ± 1a | 273 ± 14 | 4,157 ± 575 | 174 ± 9a | 2,611 ± 129 | 26 ± 2 | 383 ± 37 |
Experimental observations of Gm in AP-firing fibers were fitted to Eq. 5 and Eq. 6 to obtain parameters that describe phase 1 and phase 2, respectively. A1 describes the reduction in Gm during phase 1, and τ1 describes either the time required or the number of APs fired before 63% of A1 was observed. A2 describes the magnitude of the increase in Gm during phase 2, and τ2 describes the time or the number of APs that was fired before Gm had risen to half of A2. β reflects the steepness of the rise of Gm during phase 2. All data has been presented as means ± SEM.
All frequencies resulted in significantly different values.
Significantly different from observations at 15 and 30 Hz.