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. Author manuscript; available in PMC: 2010 Jul 15.
Published in final edited form as: J Immunol. 2009 Jun 19;183(2):814–822. doi: 10.4049/jimmunol.0803748

FIGURE 1.

FIGURE 1

Transgenic expression of βgal inhibited the immune response to βgal elicited by (A) infection with VSC 56, or by (B-C) immunization with Ag in CFA. (A) Analysis of the DTH response to βgal. Mice were ear tested with purified βgal 21 days post-infection. (B) Analysis of the specificity of tolerance in arrβgal mice. Mice were immunized with BSA/CFA and the DTH response to BSA was assayed 21 days later. (C) The regulatory activity of arrβgal mice acted on the afferent response in vivo. Recipient mice were immunized with βgal, and 30 × 106 spleen cells from control B10.A or arrβgal donor mice were transferred i.p. as indicated. DTH was analyzed by ear test 7 days post-immunization. All results are given as the mean ± SD. N = 5 - 7 mice/group. **P < 0.01 (t test) for arrβgal vs. B10.A mice.