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. Author manuscript; available in PMC: 2010 Jul 15.
Published in final edited form as: J Immunol. 2009 Jun 19;183(2):814–822. doi: 10.4049/jimmunol.0803748

FIGURE 7.

FIGURE 7

CD25+ Tregs were generated endogenously in arrβgal × βgalTCR double Tg mice. (A) Tolerance developed spontaneously in the arrβgal × βgalTCR mice on the Rag(-/-) background. Ear testing was done with βgal without prior immunization. Number of mice (N) as indicated. Results are given as the mean ± SD, P values (t test) are indicated. (B) A reduced frequency of T cells with a regulatory phenotype developed in arrβgal × βgalTCR mice. FACS analysis for CD25+Foxp3+ T cells as a percentage of the total CD3+4+ splenic T cells, N ≥ 3 for all groups. The results are given as the mean ± SD.