Table 1.
Drug Enhancers of Kit Melanocyte Defects
| Name | Source | Annotated target | Migration | Survival |
|---|---|---|---|---|
| Candidate drug enhancers of kit defects | ||||
| LY294002 | Sigma L9908 | PI3K inhibitor | Enhance | No effect |
| PD98059 | Sigma P215 | Mek inhibitor | No effect | No effect |
| Gleevec | LCLaboratories I5508 | RTK type III (Kit) kinase inhibitor | No effect | No effect |
| Drug enhancers of kit defects identified in screen | ||||
| Papaverine | Sigma P3510 | Phosphodiesterase inhibitor | Enhance | No effect |
| Isoliquiritigenin | Sigma I3766 | Guanylyl cyclase activator | Enhance | No effect |
| 8-DPAT (R-(+)-8-hydroxy-DPAT) | Sigma H140 | Serotonin agonist | Enhance | Enhance |
PI3K, phosphatidylinositol-3-kinase.