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. Author manuscript; available in PMC: 2010 Oct 2.
Published in final edited form as: Biochem Biophys Res Commun. 2009 Jul 18;387(4):671–675. doi: 10.1016/j.bbrc.2009.07.074

Fig. 1.

Fig. 1

ApoA1 increases BK half-activation voltage. (A) Currents recorded from isolated inside-out patches of HEK293 cells transfected with BK only or BK+ApoA1. Patches were stepped from −20 mV to 130 mV from a holding potential of −50 mV. Tail currents were generated by a final step back to −50 mV. (B) Average, normalized G-V curves were generated for patches containing BK-only (n = 8) and BK+ApoA1 (n = 9). Individual G-V curves were fit to Boltzmann equations and fit parameters averaged. (C) Plots of the average Gmax, half-activation voltage (V1/2), and Boltzman slope factor (Vc) are shown for the two-channel configurations. (*p < 0.05).