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. 2009 Sep 17;106(39):16622–16626. doi: 10.1073/pnas.0906146106

Fig. 3.

Fig. 3.

Enrichment plots of screening the whole PDB for (A) chymotrypsin inhibitors and (B) uracil glycosylase inhibitors. All 107,592 protein domains from PDB are ranked according to their similarity to the query patch. Protein domains that have the same function as the query protein are found to have higher similarity rank, resulting in remarkable enrichments. At the 0.1% screening range, the enrichment factors are 220 and 615 for chymotrypsin inhibitors and uracil glycosylase inhibitors, respectively. In both cases, the top 10 hits are exclusively protein-inhibitors from known lists (no false-positives).