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. 2009 Sep 10;106(39):16817–16822. doi: 10.1073/pnas.0904414106

Fig. 2.

Fig. 2.

HMGB2 and β-galactosidase expression during aging in TOPGAL mice. Safranin-O stained sections of joints from TOPGAL mice show normal cartilage at 6 months, reduced thickness and cellularity at 12 and 18 months. HMGB2 and β-galactosidase (β-Gal) are detected by immunohistochemistry at 6 months in the articular cartilage surface. At 12 months both are absent in the weight bearing areas, and HMGB2 is completely absent in the articular cartilage by 18 months. In contrast, at 18 months β-galactosidase becomes detectable in all other zones of articular cartilage except for the SZ (arrowheads). AC, articular cartilage; M, meniscus; OP, osteophyte. X100.