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. 2009 Sep 10;106(39):16817–16822. doi: 10.1073/pnas.0904414106

Fig. 3.

Fig. 3.

Synergy of HMGB2 and β-catenin. HMGB2 and β-catenin (βCA) were cotransfected with the cyclin D1 (CD1) (A and B) and TOPflash reporter genes (C–F) in SW1353 cells (A and C) and 293T cells (B and D), and luciferase assay was performed after 24 h. In SW1353 cells, HMGB2 enhances luciferase activity when cotransfected with β-catenin (A and C), whereas this synergistic effect is not seen in 293T cells (B and D). This synergistic effect is also found with TOPflash in a dose-dependent manner (F), but not with FOPflash reporter genes in ATDC5 cells (E) (*, P < 0.05).