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. 2009 Sep 15;106(39):16710–16715. doi: 10.1073/pnas.0900919106

Fig. 6.

Fig. 6.

Growth restriction, attenuated lung cell proliferation, and reduced IGF-2 levels in Erk3-deficient mice. (A) Body weight of littermate Erk3+/+ (filled bars) and Erk3−/− (open bars) embryos at various developmental stages (n = 6–12). *, P < 0.05, **, P < 0.01. (B) Lungs and heart from wild-type and Erk3−/− E18.5 embryos. (C) Ratio of lung, heart and liver weight relative to body weight in wild-type and Erk3−/− E18.5 embryos (n = 8–13). * P < 0.05, **, P < 0.01. (D) Quantification of cell proliferation assessed by Ki67 immunostaining in lung sections from Erk3+/+ (filled bars) and Erk3−/− (open bars) embryos at various developmental stages (n = 3–6). *, P < 0.05, **, P < 0.001. (E) IGF-1 and IGF-2 serum levels in E18.5 wild-type and Erk3−/− embryos (n = 8–13). *, P < 0.01.