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. 2009 Sep 15;106(39):16823–16828. doi: 10.1073/pnas.0901521106

Fig. 1.

Fig. 1.

UL97-null HCMVs that express wild-type or mutant forms of the E7 oncoprotein of HPV16. Schematic of the coding content of the UL95–UL105 region of the viruses used in this study. (A) Wild-type HCMV strain AD169 (WT); BamHI sites are labeled and an arrow representing the UL97 ORF is shown in black (top). (B) The same region of Δ97, a UL97 deletion virus is shown. A remnant 37-amino acid ORF, comprised of the first 23 amino acids of UL97 and an additional 14 amino acids attributed to a frameshift after the deletion, is shown in black; a gray box represents a remnant UL97 coding region not predicted to be translated due to a naturally occurring stop codon. (C) Δ97-E7, a UL97-null HCMV that encodes the E7 protein of HPV16 (E7, black arrow) in place of UL97. (D) Δ97-DLYC, a UL97-null HCMV that encodes a ΔDLYC mutant form of HPV16 E7 (DLYC, black arrow) in place of UL97.