Table 2.
Parametric multipoint MOD scores > 1.5 for either SCZ status (multiplicative model)
| Chr | Position (1-MOD) | Nearest Marker | Aff | MOD | Freq of A | RR | Pen of AA | Pen of Aa | Pen of aa |
|---|---|---|---|---|---|---|---|---|---|
| 3q21 | 137 cM (128–147) | D3S1589 | N | 1.95 | 0.39 | 99.84 | 0.065 | 0.00065 | 6.5 × 10−6 |
| B | 1.13 | 0.53 | 99.97 | 0.035 | 0.00035 | 3.5 × 10−6 | |||
| 9p24 | 12 cM (3–19) | D9S1686 | N | 1.40 | 0.01 | 9.86 | 0.77 | 0.078 | 0.0079 |
| B | 1.68 | 0.01 | 11.03 | >.99 | 0.091 | 0.0082 | |||
| 9q21 | 85 cM (80–96) | D9S1877 | N | 1.05 | <.01 | 10.44 | >.99 | 0.096 | 0.0092 |
| B | 2.20 | <.01 | 10.72 | >.99 | 0.093 | 0.0087 | |||
| 10q22 | 92 cM (77–112) | D10S537 | N | 1.58 | 0.01 | 11.32 | >.99 | 0.088 | 0.0078 |
| B | 0.71 | 0.17 | 4.04 | 0.072 | 0.018 | 0.0044 | |||
| 13q34 | 131 cM (115-qter) | D13S293 | N | 3.13 | 0.03 | 14.76 | >.99 | 0.068 | 0.0046 |
| B | 3.76 | 0.03 | 13.77 | >.99 | 0.073 | 0.0053 | |||
| 15q21 | 56 cM (54–65) | D15S1022 | N | 0.87 | <.01 | 10.35 | >.99 | 0.097 | 0.0094 |
| B | 1.69 | <.01 | 10.39 | >.99 | 0.096 | 0.0093 | |||
| 16p13 | 31 cM (27–45) | D16S3047 | N | 1.31 | 0.17 | 5.60 | 0.10 | 0.018 | 0.0032 |
| B | 1.64 | 0.10 | 5.64 | 0.14 | 0.026 | 0.0046 | |||
| 21q22 | 46 cM (41–48) | D21S1900 | N | 2.72 | 0.36 | 99.95 | 0.073 | 0.00073 | 7.4 × 10−6 |
| B | 1.18 | 0.52 | 99.86 | 0.037 | 0.00037 | 3.7 × 10−6 | |||
| 22q11 | 3 cM (2–9) | D22S420 | N | 1.47 | 0.44 | 99.99 | 0.049 | 0.00050 | 5.0 × 10−6 |
| B | 1.62 | 0.45 | 99.99 | 0.048 | 0.00048 | 4.8 × 10−6 |
‘A’ is the disease allele, ‘a’ is the non-disease allele. 1-MOD, region in which the MOD score is within 1 MOD score of the highest MOD score; Aff, affection classification; N, narrowly affected; B, broadly affected; Freq, allele frequency; RR, relative risk based on a 1% prevalence of SCZ; Pen, penetrance of SCZ for the given genotype. Therefore, Pen of AA is the probability of having SCZ, given two copies of the disease allele.