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. 2009 Sep 28;206(10):2271–2284. doi: 10.1084/jem.20090756

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© 2009 Beck et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 8. — A gradient of E12 and E47 activity leads to the sequential activation of the Ig light chains. Attenuation of IL-7 signaling leads to an increase in E12 and E47 expression to initiate Ig light chain gene rearrangement. Signaling through a functional BCR suppresses E12/E47 expression to prevent further rearrangements and promote positive selection and maturation. However, in the absence of such a signal, the ratio of E12 to E47 reaches a certain threshold, which enables the cell to rearrange the Igλ loci. Failure to generate a functional BCR during a certain time window will lead to cell death, presumably caused by high E12 and E47 levels.