Figure 3. Effect of NSC23925 to reverse drug resistance in MDR cell lines.
Cells were treated with the paclitaxel and NSC23925 in RPMI1640 complete media at the indicated concentrations. The relative sensitivity of each line to paclitaxe was determined by MTT analysis 6 days posttreatment. A: Reversal of paclitaxel resistance by NSC23925 in SKOV-3TR cells. B: Reversal of paclitaxel resistance by NSC23925 in OVCAR8TR cells.