Table 2. Prevalence of gallstones and rs9514089 polymorphism in the pooled Stuttgart and Aachen cohorts.
| Subgroup | Controls n (%) | Gallstone carriers n (%) | AA a< >gg c | (AA a+Ag b)< >gg c | ||||||
| Genotype | A/A | A/G | G/G | A/A | A/G | G/G | p-value | OR (95% CI) | p-value | OR (95% CI) |
| Total | 93 (37) | 129 (52) | 27 (11) | 91 (38) | 98 (42) | 47 (20) | 0.05303 | 1.78 (0.99–3.23) | 0.00767 | 2.04 (1.19–3.55) |
| Males | 47 (40) | 59 (51) | 10 (9) | 40 (42) | 34 (36) | 21 (22) | 0.05864 | 2.45 (0.97–6.55) | 0.01017 | 2.99 (1.26–7.56) |
| Females | 50 (37) | 70 (51) | 17 (12) | 51 (36) | 64 (45) | 26 (19) | 0.36153 | 1.50 (0.69–3.33) | 0.18639 | 1.59 (0.78–3.31) |
| Normal weight e | 49 (38) | 69 (53) | 11 (9) | 40 (39) | 41 (40) | 22 (21) | 0.04184 | 2.43 (0.99–6.27) | 0.00754 | 2.90 (1.27–7.01) |
| Males | 22 (43) | 27 (53) | 2 (4) | 17 (47) | 11 (31) | 8 (22) | 0.07375 | 5.01 (0.85–54.42) | 0.01410 | 6.85 (1.25–70.70) |
| Females | 27 (35) | 42 (54) | 9 (11) | 23 (34) | 30 (45) | 14 (21) | 0.31514 | 1.81 (0.60–5.71) | 0.17103 | 2.02 (0.75–5.71) |
| Overweight f | 44 (37) | 60 (50) | 16 (13) | 51 (38) | 57 (43) | 25 (19) | 0.45777 | 1.35 (0.60–3.07) | 0.30547 | 1.50 (0.72–3.20) |
| Males | 25 (39) | 32 (49) | 8 (12) | 23 (39) | 23 (39) | 13 (22) | 0.30883 | 1.75 (0.55–5.85) | 0.16034 | 2.00 (0.70–6.09) |
| Females | 19 (35) | 28 (51) | 8 (14) | 28 (38) | 34 (46) | 12 (16) | 1.00000 | 1.02 (0.31–3.46) | 1.00000 | 1.14 (0.39–3.48) |
p<0.05 was regarded as statistically significant, odds ratio (OR) and 95% confidence interval (CI).
a
AA = major allele.
b
Ag = heterozygote allele.
c
gg = minor allele, the subjects were divided into subgroups with body mass index (BMI)≤25 kg/m2 = e normal weight and BMI>25 kg/m2 = f overweight.