Figure 4.

Lovastatin suppresses NMDA-induced GSK3 truncation and GSK3β activation in primary neurons. A, Lovastatin pretreatment attenuates the GSK3 truncation induced by NMDA exposure. The representative Western blots and densitometry analysis of GSK3 truncation are shown. Data are presented as the mean ± SD. *p < 0.001 versus untreated; **p < 0.001 versus NMDA. B, Lovastatin suppresses GSK3β activation upon NMDA. GSK3β activity was measured by the Ser 9 phosphorylation which inversely correlates with its enzymatic activity. Densitometry analysis of pGSK3β/GSK3β ratio is shown in the bar graph. Data are presented as the mean ± SD. *p < 0.001 versus untreated; **p < 0.001 versus NMDA.